Changes in Membrane Protein Structural Biology
نویسندگان
چکیده
منابع مشابه
Membrane protein structural biology minireview series.
It is estimated that one-third of all proteins are integral membrane proteins, defined narrowly as proteins that completely traverse the membrane bilayer. There also exists a smaller but unknown number of monotopic membrane proteins, including prostaglandin endoperoxide H synthases, that interdigitate into a single leaflet of the lipid bilayer via a specific membrane binding domain (1). Additio...
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Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts. This review provides an overview of this important field, focusing in particular on the recent resurgence of electron microscopy (EM) and the increasing role it has to play in the structural studies of membr...
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ژورنال
عنوان ژورنال: Biology
سال: 2020
ISSN: 2079-7737
DOI: 10.3390/biology9110401